Synthesis. A 3 things, 3 levels Box-Behnken factorial design and style was utilized for fitting a second order response surface, applying the software Design Specialist 7.1.1 (Stat-Ease, Minneapolis, MN, USA). All other components, for instance reaction time, molecular sieves content material had been maintained constant. A mathematical model, describingSun et al. Chemistry Central Journal 2013, 7:114 http://journal.chemistrycentral/content/7/1/Page 13 ofAuthor information 1 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P.R. China. 2Jiangxi Provincial Engineering and Technology Center for Food Additives Bio-production, Dexing 334221, P.R. China. 3Parchn Sodium Isovitamin C Co. Ltd, Dexing 334221, P.R. China. Received: 9 May perhaps 2013 Accepted: four July 2013 Published: 8 July 2013 References 1. Alan AF: Final Report on the Security Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Erythorbic Acid, and sodium Erythorbate. Int J Toxicol 1999, 18:1?six.Gold(III) chloride trihydrate Price two.Price of AN-12-H5 intermediate-1 CFR-Code of Federal Regulations Title 21.PMID:33679749 http://accessdata.fda.gov/ scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.3041. 3. Song QX, Wei DZ: Study of Vitamin C ester synthesis by immobilized lipase from Candida sp. J Mol Catal B: Enzym 2002, 18:261?66. 4. Lv LX, Pan Y, Li YQ: Biosynthesis of ascorbyl benzoate in organic solvents and study of its antioxygenic and antimicrobial properties. Meals Chem 2007, 101:1626?632. 5. Song QX, Wei DZ, Zhou WY, Xu WQ, Yang SL: Enzymatic synthesis and antioxidant properties of L-ascorbyl oleate and L-ascorbyl linoleate. Biotechnol Let 2002, 26:1777?780. 6. Fidler MC, Davidsson L, Zeder C, Zeder RF: Erythorbic acid is really a potent enhancer of nonheme-iron absorption. Am J Clin Nutr 2004, 79:99?02. 7. Adamczak M, Bornscheuer UT, Bednarski W: Synthesis of ascorbyloleate by immobilized Candida antarctica lipases. Course of action Biochem 2005, 40:3177?180. 8. Park KM, Lee DE, Sung H, Lee JH, Chang PS: Lipase-catalysed synthesis of erythorbyl laurate in acetonitrile. Meals Chem 2011, 129:59?three. 9. Burham H, Rasheed RAGA, Noor NM, Badruddin S, Sidek H: Enzymatic synthesis of palm-based ascorbyl esters. J Mol Catal B: Enzym 2009, 58:153?57. ten. Chang SW, Yang CJ, Chen FY, Akoh CC, Shieh CJ: Optimized synthesis of lipase-catalyzed l-ascorbyl laurate by Novozym?435. J Mol Catal B: Enzym 2009, 56:7?2. 11. Duarte DR, Cortes NL, Torres P, Comelles F, Parra JL, Ugidos AV, Ballesteros A, Plou FJ: Synthesis and Properties of Ascorbyl Esters Catalyzed by Lipozyme TL IM applying Triglycerides as Acyl Donors. J Am Oil Chem Soc 2011, 88:57?four. 12. Wong CH, Whitesides GM: Enzyme in Synthetic Organic Chemistry Tetrahedron Organic Chemistry. Oxford, UK: Pergamon Press; 1994. 13. Lerin LA, Feiten MC, Richetti A, Toniazzo G, Treichel H, Mazutti MA: Enzymatic synthesis of ascorbyl palmitate in ultrasound-assisted program: course of action optimization and kinetic evaluation. Ultrason Sonochem 2011, 18:988?96. 14. Malcata FX, Reyes HR, Garcia HS, Hill CG, Amudson CH: Immobilized lipase reactors for modification of fats and oils ?a review. J Am Oil Chem Soc 1990, 67:890?10. 15. Karmee SK: Biocatalytic synthesis of ascorbyl esters and their biotechnological applications. Appl Microbiol Biotechnol 2009, 81:1013?022. 16. Chang SW, Yang CJ, Chen FY: Optimized synthesis of lipase-catalyzed l-ascorbyl laurate by Novozym?435. J Mol Catals B Enzym 2009, 56:7?two. 17. Bezbradica D, Stojanov M, Velckov D: Kinetic model of lipase-catalyzed conversion of ascorbic acid and oleic acid to liposoluble vitami.