Product Name :
MS-436
CAS :
1395084-25-9
Formula :
C18H17N5O3S
MW:
383.4
Description :
MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 ?M, respectively). MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.
Purity :
98%
Ships Within:
24 Hours
Storage Condition :
-20°C
Shipping :
Ambient Temperature
Availability :
In Stock
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